可以。8.0.16之前的版本在升级后需要手工运行mysql_upgrade来升级系统表。自从8.0.16以后，这个工作由可以在启动的时候自动完成了。

参考：https://dev.mysql.com/doc/relnotes/mysql/8.0/en/news-8-0-16.html

另外根据https://dev.mysql.com/doc/refman/8.0/en/upgrade-paths.html，如果升级前和升级后的版本都是GA版本，那么就可以直接升级：

Once a release series reaches General Availability (GA) status, upgrade within the release series (from one GA version to another GA version) is supported. For example, upgrading from MySQL 8.0.x to 8.0.y is supported. (Upgrade involving development-status non-GA releases is not supported.) Skipping a release is also supported. For example, upgrading from MySQL 8.0.x to 8.0.z is supported. MySQL 8.0.11 is the first GA status release within the MySQL 8.0 release series.
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可以，重新启动后会自动升级。